In the documentary Strain Hunters Swaziland, the Strain Hunters team travels to Eswatini (formerly Swaziland), a small landlocked country between South Africa and Mozambique, to explore and document the local cannabis culture. The expedition highlights the economic and cultural importance of cannabis for the people of this region.

Eswatini is known for its beautiful natural parks and diverse flora and fauna, but it is also one of the largest cannabis producers in Africa, despite its small geographic size. The local strain, known as "Swazi Gold," is particularly sought after. The documentary explores how cannabis is cultivated, processed, and used by the local population, often as a vital source of income in a region marked by poverty and high HIV infection rates.

The Strain Hunters team, consisting of Arjan, Franco, and Simon, interacts with local growers and discovers the challenges they face, as well as the traditional methods of cannabis cultivation. The documentary provides insight into local agricultural practices and the socio-economic impact of cannabis on the lives of the inhabitants.